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Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or MEN 2

The key difference between Tirzepatide and Retatrutide is the number of metabolic pathways they activate

For the calculation of percentage of weight regain from week 36 to week 88 relative to week 36, missing weight measures at week 88 were imputed by predictions using observed data through a mixed model for repeated measures adjusted for week 0 value, week 36 value, country, sex, and maximum tolerated dose of tirzepatide at week 36

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