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J Physiol Pharmacol 61:301307 Walker J, Jijon HB, Diaz H, Salehi P, Churchill T, Madsen KL (2005) 5-Aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK

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Baseline hepatic steatosis was assessed by ultrasonography

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Adjusting dosage or addressing lifestyle factors often resolves these plateaus, enhancing continued effectiveness