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Results Our cohort included 4144 liraglutide, 613 semaglutide, and 654 bupropion-naltrexone users

Role of GLP-1RAs in IR Associated with PCOS The GLP-1RAs, also known as incretin mimetics, are a group of drugs that imitate the activity of the incretin hormone GLP-1 secreted in the distal part of the small intestine [67]

These include nausea, vomiting, bloating, stomach pain, diarrhea, constipation, and indigestion

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However, its relatively short plasma half-life of 23 min, due to rapid degradation by dipeptidyl peptidase-4 (DPP-4), has prompted structural modifications to enhance its pharmacological efficacy