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The increased adipose tissue associated with obesity leads to greater friction between skin folds, enhancing the occlusion of follicular and sebaceous units and further promoting the expression of pro-inflammatory cytokines [24,25]

If you add the same 2ml of bacteriostatic water, you get a concentration of 5mg/ml instead of 2.5mg/ml

LRP5 primarily encodes the transmembrane LDL receptor, which facilitates Wnt protein signaling and participates in other processes, including skeletal development

Meaning, its more likely to occur and even worsen at higher doses

Authors of the psychiatric study stated clearly that more randomized clinical trials are needed before stronger conclusions can be made