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Intracellular cAMP sensor EPAC: Physiology, pathophysiology, and therapeutics development
Thyroid 35 , 6978 (2025)

18 Obesity is an important contributor to the pathophysiology of both diabetes and HF, particularly HFpEF
In vitro experiments found compound 31 (Figure 5) to be the most potent, as predicted by in-silico simulations, with an IC 50 of 3.16 M

Review Article OPEN ACCESS Lun-Gen Lu * Author information Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently a pressing public health issue associated with adverse outcomes such as cirrhosis, malignancy, transplantation, and mortality
