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However, previous studies have found that DPP-4 can be regulated by inflammatory factors such as signal transducer and activator of transcription 1 (STAT1), hepatocyte nuclear factor-1 (HNF-1), interleukin-12 (IL-12), and tumor necrosis factor- (TNF-) [3335]

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They also observed that participants who lost more weight in the first year after surgery had a greater absolute weight loss over time

Slower dose titration, consistent injection timing, proper site rotation, and small frequent meals may reduce headache frequency and severity

These symptoms are typically most pronounced during the initial weeks of treatment or following dose increases, as the body adjusts to the medication's effects on gastric emptying and satiety signalling