do you plateau on tirzepatide Plateau: Why It Happens & What Works Tirzepatide Weight Loss Plateau: 9

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If side effects are partly peak-driven, a higher abdominal peak could plausibly trigger more early GI symptoms even when total exposure is similar

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There is also a theoretical concern that intramuscular injection might cause local tissue irritation or injection site reactions , though tirzepatide generally has a relatively low incidence of injection site adverse events in clinical trials