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Based on Phase 2 data at 12mg: approximately 23% by week 4, 812% by week 12, 17.5% by week 24, 24.2% by week 48

However, another study by Storgaard et al

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"Publication of the TRANSCEND data in NEJM underscores both the strength of the clinical evidence and the potential positive impact of setmelanotide for people living with acquired hypothalamic obesity," said David Meeker, M.D., Chairman, President, and Chief Executive Officer of Rhythm Pharmaceuticals