sglt2 inhibitors and glp-1 receptor agonists Combining in Type 2 Diabetes Mellitus: A Scoping Review and Expert Insights for Clinical Practice Utilizing the Nominal Group Technique SGLT2 Inhibitors vs. GLP-1 Agonists
Description
Preserved incretin activity of glucagon-like peptide 1 [736 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

SURPASS-CVOT compared once-weekly tirzepatide with dulaglutide in adults with type 2 diabetes and high cardiovascular risk, showing a 9% relative risk reduction in MACE (HR 0.92, 95% CI 0.83 to 1.01)
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Lau J, Bloch P, Schffer L, Pettersson I, Spetzler J, Kofoed J, et al

Just three years later, in 2022, the game shifted again with tirzepatide (Mounjaro)

The question isn't whether you'll lose some lean mass
