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If there are no GI AEs, then, in the authors clinical experience, uptitration may be performed rapidly, for example, increasing to the next dose after 24 weeks, although the lower end of this range may not be in accordance with the product label and cost may need to be considered when deciding on an uptitration schedule

Off-label use typically requires private prescription

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And it can cross the blood-rain barrier, reduce inflammation and oxidative stress, and protect synapses and neurons, showing neuroprotective effects in animal models of AD and PD (Hong et al., 2024)

NICE recommends these agents particularly for patients with established cardiovascular disease, heart failure, or chronic kidney disease