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The most common side effect of the GLP-1RA class is GI-related adverse events (AE) including nausea, diarrhea, and vomiting (129) which are dose-dependent and typically present in the up-titration phase

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This is a medication that works by influencing appetite and digestion, and as your body adjusts, certain symptoms can occur especially in the first few weeks

The broader opportunity may lie in how these therapies reshape the ecosystem around weight management, nutrition, and preventive healthcare

Follow-on versions of liraglutide and semaglutide, and possibly other polypeptides, should be clinically evaluated for efficacy and safety