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Patients should contact a clinician if they experience persistent vomiting, severe abdominal pain, signs of dehydration, severe constipation, worsening reflux, dizziness, low blood sugar symptoms, confusion about dosing, or inability to eat enough protein and fluids

In fact, an early report in rats described an increase in energy expenditure during the first hours of the dark cycle following i.c.v

A good care plan should consider both

It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients

Changes in diet, hydration, sleep, and activity levels during travel interact with medication effects in ways that catch people off guard