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The SmPC specifically advises monitoring renal function when patients experience severe gastrointestinal adverse reactions

[6] [12] The medication is not recommended for patients with severe gastrointestinal disease, including severe gastroparesis

doi:10.1097/GRF.0000000000000567 Vaidya VR, Arora S, Patel N, et al

Within the first weeks to months of treatment, you may start noticing that any food noise is quieting down, you have fewer cravings, and you get full sooner during a meal and longer afterwards

Where Microdosing May Cost More Extended duration: If microdosing extends treatment from 12 to 18-24 months, you pay more total despite lower monthly costs