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tirzepatide surpass-5 Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial New Dual Incretin Agonist for
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The incidence of thyroid cancer in semaglutide-treated patients was less than 1%, suggesting no significant risk [19]

Tirzepatide binds the GLP-1 receptor with lower affinity than semaglutide and exhibits distinct signaling bias, which may result in comparatively different downstream GLP-1 receptor signaling dynamics 23