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In many cases, the overall effect on the medication's therapeutic action is not significant, but the efficacy of some drugs (see below) may be altered

While GLP-1 (7-36amide) and GLP-1 (737) are equally potent to stimulate the secretion of insulin and c-peptide [181], GLP-1 (137) has a much lower insulinotropic efficacy [[80], [81], [82]]

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AAAAI guidance shows no contraindication with GLP-1 meds

GLP-1 RAs also interact with the renin-angiotensin-aldosterone system (RAAS) but consistent changes in angiotensin II or aldosterone levels have not been demonstrated