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[13] In the other five trials (NCT01930188, [69] NCT01885208, [70] NCT02128932, [71] NCT02207374, [72] and NCT02254291 [73] ), participants were randomly assigned to receive either semaglutide or another anti-diabetic medication, and the participant and provider knew which medication was being given in four trials

The Trp33 dependence described above means the compound does not effectively activate the native rodent GLP-1 receptor, because rodents carry serine, not tryptophan, at that position
