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Furthermore, site-specific conjugation ensures that the receptor-binding domain remains accessible, thereby preserving bioactivity while minimizing off-target immunogenic responses
The authors connect this to something known as the rate hypothesis in addiction research: the faster a substance hits the brain, the stronger and more rewarding it feels

GLP-1s are powerful hormones
Intriguingly, although tirzepatide closely resembles native GIP in how it activates the GIPR, it differs markedly from GLP-1 in its activation of the GLP-1R, resulting in less agonist-induced receptor desensitization
Glasson, S
