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Treatment of gastroparesis: a multidisciplinary clinical review

Interestingly, RANTES and its receptor CCR5 are important mediators of obesity-induced inflammation, which was shown in CCR5-KO mice (91)

The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) ( Figure 2 )

If treatment is prescribed, your care continues under medical supervision, with support to help manage tolerability and adjust dosing when needed

Good nutrition + physical activity carry far fewer adverse risks