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The synergistic pharmacological mechanisms of GLP-1 RAs combined with metformin may modulate the expression of reproductive function-related hormonal indicators, thereby ameliorating endocrine disturbances and restoring normal menstrual cycles

For most patients this doesn't matter clinically, but for patients sensitive to specific preservatives (benzyl alcohol is common in compounded formulations), it can trigger injection site reactions

Some people need 34 weeks or a higher dose to experience strong appetite control

Semaglutide is generally well-tolerated, but some patients may experience mild side effects, especially when first starting treatment

[DOI] [PubMed] [Google Scholar] 75.Natarajan K, Xie Y, Baer MR, Ross DD