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Researchers are investigating genetic variants in GLP-1 receptor pathways, gut microbiome profiles, and baseline hormone levels to determine who will respond best to GLP-1 therapy, who might benefit from dual agonists, and who is more prone to side effects

In terms of lowering HbA1c, dulaglutide, when administered once a week, was demonstrated to be more effective than exenatide twice a day, by 1.51% vs.0.99% [94]

Others have moved in the opposite direction, limiting coverage due to budget concerns

A 2016 review of studies showed that this Exenatide injection led to a more significant reduction of body weight and body mass index (BMI)

Patients who achieve lasting results combine semaglutide with a support program that prepares them to lead a healthier lifestyle