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9% with placebo (a substance that has no therapeutic effect), nausea (13%, 18% and 16%) vs

In agreement, GLP1R agonists have been reported to reduce hepatocarcinogenesis in non-obese chemical carcinogen-induced mouse models of HCC, perhaps by limiting liver pro-tumorigenic metabolic factors such as hepatic insulin resistance, steatosis and inflammation 90,91

While the inflammation-reducing and fibrosis-attenuating effects of glucagon agonism are less well-characterized, the reductions in hepatic inflammation parameters and fibrosis observed in preclinical models likely reflect secondary effects consequent to improved steatosis, rather than direct anti-inflammatory actions [21]

Based on the best nationally representative data available today, about 15% of adult women in the United States are currently using a GLP-1 medication, according to KFF