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Tirzepatide Activates both GIP and GLP-1 receptors Targets two metabolic pathways Supports appetite regulation and metabolic function Classified as a dual receptor agonist Semaglutide Activates GLP-1 receptors only Targets a single metabolic pathway Supports appetite regulation and blood sugar control Classified as a GLP-1 receptor agonist Both medications are peptides, but tirzepatides dual-receptor activity makes its mechanism of action distinct

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Pharmaceutical medications such as semaglutide-based drugs mimic this hormone and are commonly prescribed for obesity or type 2 diabetes

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The AWARD-1 trial showed that dulaglutide was superior to exenatide, while the AWARD-6 trial showed that it was not inferior to liraglutide [50]

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Martin-Rodriguez E, Guillen-Grima F, Marti A, Brugos-Larumbe A

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Corticostriatal pathways contribute to the natural time course of positive mood

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