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Direct injection of Ex-4 into the nucleus accumbens (NAc) or ventral tegmental area (VTA) reduces food reward without causing visceral illness (Dossat et al., 2011

The subsequent weight loss seen by many on these drugs may also contribute to increased fertility

Tirzepatide is a dual-agonist , meaning it works by targeting two hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Retatrutide is a triple-agonist , meaning it targets three hormones: GLP-1: helps regulate appetite, blood sugar, and digestion GIP: supports insulin response and reduces nausea Glucagon: affects energy use and fat metabolism Early studies show that retatrutide may be more successful than tirzepatide at managing diabetic kidney disease, as well as for weight control, while tirzepatide may be better at managing blood glucose

Supporting these interconnected systems may help improve how metabolic signaling functions over time