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The specific mechanism of how GLP-1RAs can cross the blood-brain barrier and reach the hypothalamus has been a matter of debate

For the most up-to-date criteria, refer to the relevant NICE technology appraisals or speak to your GP

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Meta-analyses of phase 3 randomised controlled trials of third generation aromatase inhibitors versus tamoxifen as first-line endocrine therapy in postmenopausal women with hormone receptor-positive advanced breast cancer

Cardiovascular outcome trials (CVOTs) have consistently validated the safety of GLP-1RAs in individuals with type 2 diabetes, with several studies also demonstrating their potential to reduce stroke risk [37]