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Nat Med 23:107113

This is a top-down approach the brains chemistry is altered to reduce the drive to eat

Clinical Observations and Evidence Recent clinical data published in the New England Journal of Medicine demonstrated that standard-dose semaglutide administration resulted in an average 15% reduction in body weight over 68 weeks
These views are shaped by clinical experiences, existing research, and the ongoing evolution of diabetes and obesity management practices

For example, California (Medi-Cal) covers Zepbound for weight management with no prior approval