fda label semaglutide naion warning 2025 The signal observed with continues to generate discussion. A new hypothesis suggests this may not represent direct optic nerve toxicity, but rather an ocular version of the “early worsening” phenomenon Saxenda Lawsuit - Vision Loss

It also promotes the use of stored fat for fuel, may reduce appetite, and early studies suggest it could help reduce liver fat too

This counteracts the metabolic adaptation that derails so many weight loss attempts in midlife women

Even though weight loss reaches a plateau after about a year or so, people who take a GLP-1 RA for weight loss might still prefer to stay on it for the long term

Furthermore, increases in hemoglobin A1c heightened the risk of retained gastric contents ( In our study, there was also an increased risk for those with hemiplegia and CKD (Figure 3)

However, high doses also bring an increased risk of adverse effects