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doi: 10.1016/j.lfs.2020.118548 [DOI] [PMC free article] [PubMed] [Google Scholar] 177.Saengboonmee C, Sorin S, Sangkhamanon S, et al

The observation that the induced effect on insulin secretion is different when oral glucose was administered versus the same amount of glucose parenterally coined the term incretin effect, supporting the idea that some substances secreted in the intestines favored the release of insulin after ingestion [1]

When administered in humans, GIP receptor antagonists conjugated to GLP-1 analogues have led to mild gastrointestinal-related adverse events, including nausea and vomiting (50)

doi: 10.1186/s13063-019-3259-x
(e) inhibition of hepatic PEPCK and glucose-6-phosphatase, thereby decreasing gluconeogenesis [32]
