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The top 100 differentially expressed genes were selected based on the BH-adjusted P values
in a study of black-box warnings issued from 2007 to 2015, 29% were entirely new, 32% were considered major updates to existing black-box warnings, and 40% were minor updates
The next wave includes molecules that agonize three or more receptors
It also indicates that the MDL is entering a more substantive stage as Judge Marston gets ready to handle expert and causation issues before any bellwether trials
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And we do have people who stopped taking the drug and a year later are still vomiting
