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This has driven interest in multi-faceted therapies that target several metabolic pathways at once to enhance efficacy while minimizing side effects

Constipation and diarrhea may occur as semaglutide slows stomach emptying and alters gut motility, but these effects typically stabilize within 4-8 weeks

For those following the development of retatrutide with a view to future use, it is worth noting that NICE guidance on obesity pharmacotherapy including its technology appraisal of semaglutide (Wegovy) for weight management does not specify a preferred time of day for weekly injectable agents

Compounded semaglutide provides the same active ingredient at more accessible prices