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Individuals with diabetes taking semaglutide may be at a 4x greater risk for developing NAION

2024 [cited 2025 December, 20]

[DOI] [PubMed] [Google Scholar] 27.Kromann C.B., Deckers I.E., Esmann S., Boer J., Prens E.P., Jemec G.B

Cadmium-induced neurotoxicity, reflected by decreased A42, p-tau, acetylcholine, and GABA in the hippocampus along with increased toxic glutamate, triggers cognitive impairment and Alzheimer-like changes

13 Both endogenously secreted GLP-1 and GIP are quickly cleared following release due to both renal clearance and rapid metabolism by the enzyme DPP-4
