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Clenbuterol is a beta-2 agonist that increases metabolic rate through sympathetic nervous system stimulation, with significant cardiovascular risks

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Pharmacol Ther 113:546593 Moffett RC, Patterson S, Irwin N, Flatt PR (2015) Positive effects of GLP-1 receptor activation with liraglutide on pancreatic islet morphology and metabolic control in C57BL/KsJ db/db mice with degenerative diabetes

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Future research should also investigate the biological mechanisms underlying the apparent reduction in GLP-1 RA efficacy among BC patients receiving endocrine therapy
