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This study was corroborated by another study by Diamant et al., where HDL-C levels nonsignificantly changed from the baseline following treatment with exenatide once weekly (0.00 mmol/L) [67]

Phase 2 data shows 24.2 percent weight loss over 48 weeks at the 12 mg dose, the largest reported for any peptide in the class

Patients with diabetes face additional risk, as dehydration can precipitate diabetic ketoacidosis in susceptible individuals

Storage Information Most solid oral drugs have a longer shelf life when stored at room temperature (6877F / 2025C) and shielded from UV radiation in airtight containers

The most common side effects of tirzepatide are gastrointestinal: Nausea: Reported by 12-33% of participants depending on dose (most common early in treatment) Diarrhea: 12-21% of participants Constipation: 6-11% of participants Vomiting: 5-13% of participants Decreased appetite: Expected therapeutic effect but can be uncomfortable These side effects are typically most intense during the first few weeks at each new dose level and tend to improve as the body adjusts