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GLP-1RA (such as exendin-4) treatment can reduce the size of MI impacted cardiac volume in rats, inhibit ventricular dilation, myocardial fibrosis and hypertrophy in vivo [72]

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are approved for type 2 diabetes (T2D), and some are also indicated for reduction of the risk of atherosclerotic CVD in T2D and for weight management

The pre-proglucagon system constitutes interesting candidates as potential targets for new anti-obesity drugs

Then, we analyzed BAT activation and the effect of G49 in elevating Ucp1 mRNA and protein levels and BAT temperature was blunted in ATGL adipoCre mice (Fig

[DOI] [PubMed] [Google Scholar] 145.Navaneethan S.D., Bansal N., Cavanaugh K.L., Chang A., Crowley S., Delgado C., Estrella M.M., Ghossein C., Ikizler T.A., Koncicki H., et al