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Consequently activities of the GLP-1R effectors, PKA to inhibit channel activation (through ADP binding), and Epac to facilitate channel inhibition (through ATP binding), result in a coordinated potentiation of glucose-initiated cell membrane depolarization

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Molecular Mechanism: The GLP-1R Signaling Pathway The expression of GLP-1R in the brain is not limited to neurons in specific brain regions including the frontal cortex, hypothalamus, thalamus, hippocampus, cerebellum, and substantia nigra but also includes microglial cells involved in neuroinflammation

For the first 2.5 h post-dosing, mean ICP was calculated from each 30 min of continuous ICP monitoring

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