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Intensive glucose control and macrovascular outcomes in type 2 diabetes

In animal studies, GLP-1RA exposure was associated with reduced fetal growth, delayed skeletal ossification, and reductions in maternal weight gain and food consumption (109)

Kolijn D, et al

In addition, it attenuates the nuclear translocation of NFATc1, a crucial downstream effector of the RANKL signaling pathway that is indispensable for the terminal stage of osteoclast differentiation (Mabilleau et al., 2016)

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