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This often results in an average weight loss of about 15% when paired with lifestyle changes

Holt MK, Richards JE, Cook DR, et al

How Ozempic Works Semaglutide Molecule GLP-1 receptor agonist

Important safety considerations include risk of acute pancreatitis (seek urgent medical attention for severe, persistent abdominal pain), gallbladder disease, dehydration leading to acute kidney injury with severe gastrointestinal effects, and potential worsening of diabetic retinopathy, particularly with rapid improvement in blood glucose control

This is likely to have been driven by the additional weight loss in the placebo arm compared to the relative weight gain after cessation of GLP-1 therapy in the liraglutide arm