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(PDF) Ulke, C., Kayser, J., Tenke, C.E., Mergl, R., Sander, C., Panier, L.Y.X., Alvarenga, J.E., Fava, M., McGrath, P.J., Deldin, P.J., McInnis, M.G., Trivedi, M.H., Weissman, M.M., Pizzagalli, D.A., Hegerl, U., Bruder, G.E

Clinical decisions, including whether a prescription is appropriate, are made solely by the evaluating clinician

Like semaglutide, orforglipron mimics a hormone in the body called GLP-1, helping people to feel fuller for longer as well as increasing insulin production, among other actions

Cell Metab 2019;30:98796.ArticlePubMedPMC 26

GLP-1 also prevents pancreatic -cell apoptosis54) by controlling the expression of bcl-2 (antiapoptotic protein) and caspase-3 (pro-apoptotic protein)