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The medications full effectiveness builds as the dose is gradually increased
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Increased sugar intake as a form of compensatory hyperphagia in patients with type 2 diabetes under dapagliflozin treatment
The same pattern holds for tirzepatide
Given that the two major defects in type 2 diabetes are insulin resistance and impaired insulin secretion, metformin is recommended for use in combination with insulin secretogogues and even with intensive insulin therapy [1]
