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Hunt SA, Abraham WT, Chin MH, et al

The total body weight, bone mineral density (BMD), and bone turnover markers (BTMs) [C-terminal telopeptide of type 1 collagen (CTX) and procollagen type I N-propeptide (P1NP)] were measured at baseline and 20 weeks

Clinically, retatrutide has been demonstrated to decrease visceral fat mass without sacrificing lean muscle, which is crucial for metabolic health and mitigating obesity-related risks

It's important to understand that changes in these biomarkers are surrogate endpoints and have not been validated as a basis for selecting specific GLP-1 receptor agonists for anti-inflammatory purposes

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