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These risks highlight the importance of professional guidance

This shift in use was largely propelled by findings from pivotal clinical trials like STEP (Semaglutide Treatment Effect in People with Obesity) and SURMOUNT (the brand name of Eli Lillys clinical trial program)

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However, the temporal dynamics and mechanisms underlying insulin resistance development in AD remain unclear

For instance, exenatide, the first GLP-1-analogue developed, demonstrated to promote human monocyte differentiation into alternatively activated M2 macrophages, leading to an increase in anti-inflammatory cytokines such as IL-10 while significantly reducing pro-inflammatory cytokines, including IL-6, TNF- and IL-1 ( Furthermore, GLP-1 has been hypothesised to act as a mediator between innate and adaptive immune responses