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A further drive to utilise GLP-1 RAs arises from the cardiorenal benefits offered with some of the therapies
Astrocytic activation, indicated by glial fibrillary acidic protein(GFAP) expression, was also notably decreased in the cortex and hippocampus, suggesting a reduction in neuroinflammatory responses

If you lose a significant amount of muscle, your metabolism can slow down, making it easier to regain weight later
The peak increase in GIP levels in response to a high-fat meal (450 kcal containing 33.3% fat) is three times higher than that observed during a 75 g oral glucose tolerance test (OGTT) in healthy subjects, indicating that GIP is robustly stimulated by fat content in a mixed meal [50]

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