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While gastrointestinal side effects were common, they were mostly not acute

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A reduction in body weight was observed with ZEPBOUND irrespective of age, sex, race, ethnicity, baseline BMI, and glycemic status

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During the 36-week open-label ZEPBOUND lead-in period, ZEPBOUND dosages were escalated over a period of up to 20 weeks to an MTD of 10 mg or 15 mg subcutaneous once weekly

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Rated 4 out of 5 Brittany (verified owner) Some mild nausea a few days after each dose but seems to still help curb appetite and keep weight off Rated 5 out of 5 Julia (verified owner) Amazing results

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Eli Lilly has stated it "remains confident in the differentiated benefits of tirzepatide." Facing generic competition, Novo Nordisk has taken several steps: Launch of rebranded versions In December 2025, Health Canada approved two Novo Nordisk rebranded versions on December 22: These are identical to the branded versions but come in different packaging

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