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Compounding this plateau, placebo-controlled cardiovascular outcome trials (CVOTs) are increasingly deemed unethical in patients with established CVD, as current standards of care now include agents with proven cardiovascular efficacy, namely GLP-1RA and SGLT-2 inhibitors

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Women are already overwhelmed by the wave of GLP-1 medication messaging that has redefined the cultural conversation around bodies, appetite, and health

In the SUSTAIN-6 trial, semaglutide demonstrated cardiovascular benefits in adults with type 2 diabetes at high cardiovascular risk, though it is important to note this is not a UK-licensed cardiovascular indication

Some research has linked GLP-1 agonists to serious digestive problems such as stomach paralysis, pancreatitis and bowel obstructions, although the risks of these events appear to be rare