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The week-by-week weight loss timeline shows that the curve accelerates as doses increase

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The medication may need to be temporarily discontinued 5-14 days before surgery

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The Phase 2b IMPACT trial demonstrated MASH resolution without worsening fibrosis, with weight losses of 4-6% over 24 weeks at current doses

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Additionally, weight loss can be enhanced by engaging in a consistent exercise routine that includes cardio exercise and strength or resistance training

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