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Arrestin1 mediates glucagonlike peptide1 signaling to insulin secretion in cultured pancreatic cells

GLP-1-Based Strategies for the Treatment of T2DM A GLP-1-based strategy for the treatment of T2DM is indicated in view of the fact that GLP-1R agonists and DPP-IV inhibitors exert a beneficial constellation of physiological effects that include (1) glucose-dependent stimulation of insulin secretion, (2) suppression of glucagon secretion, (3) normalization of blood glucose without an attendant risk of hypoglycemia, (4) slowing of gastric emptying, (5) appetite suppression, and (6) weight loss

Bharucha AE, Locke GR, Murray JA

Estrogen decline already accelerates bone resorption, and the Hansen trial specifically enrolled adults with increased fracture risk