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Seattle (WA) (1993)
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A 2022 systematic review and meta-analysis published in JAMA Internal Medicine found that GLP-1 receptor agonists were associated with increased risks of biliary disease compared to other diabetes medications, with higher risk observed at weight-loss doses and with longer duration of treatment

And the evidence that they help with weight loss
11 A 2025 study of fully automated digital CBT-I across multiple clinical trials found that it had moderate to large effects on the severity of insomnia when compared to control groups
