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Data extracted from the selected studies included: study design, sample size, participant demographics, diagnostic criteria, intervention details, comparator, duration of treatment, outcome measures, key efficacy and safety results, and limitations

One traditional approach involves two separate operations, the first to remove the disease and divert the intestinal contents to a colostomy bag on the skin, and the second, several months later, to hook the colon and rectum back together (see Figure 3)

As for safety, the mid-stage trial found Ziihera to be well-tolerated, with only two patients discontinuing treatment due to toxicities