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ligand binding makes the cleavage site accessible, leading to shedding of the Notch ectodomain as the first step of signal transduction [[3][3], [4][4]]

Of course, wider availability must go hand in hand with: careful patient selection proper dose escalation counselling on gastrointestinal adverse effects long-term adherence and responsible, evidence-based prescribing A small but historic moment in clinic today: my first prescription of generic semaglutide in India

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