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Science2011 Jun 17;332(6036):1433-5
GLP-1 (Glucagon-Like Peptide-1) Delayed gastric emptying (lowers appetite and promotes extended satiation) Increased secretion of insulin Lowered glucose levels GIP (Glucose-dependent Insulinotropic Polypeptide) Increased uptake and storage of glucose Elevated fatty acid uptake Increased secretion of insulin GCG (Glucagon) Elevated lipolysis and energy expenditure Increased secretion of insulin Promotion of satiety (feeling full) Prior work on developing triple receptor agonist molecules shows a synergistic effect between GLP-1, GIP and GCG when said molecule is optimized to adequately target their respective receptors
While not always explicitly mandatory, their diet plans are often structured in a way that makes their proprietary food products almost essential for adherence
The patients started on low doses and increased gradually, reaching the full Wegovy dose over 72 weeks
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