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Current Status: Mixed but advancing

Long-term pharmacovigilance planning, adverse event characterization, real-world evidence generation, and post-marketing surveillance strategies are therefore not secondary considerations, but essential pillars of responsible therapeutic development

One genetic study described an enhanced effect on cocaine use in GLP-1R knockout mice achieved via viral-vector delivery of the gene encoding for GLP-1R to the dorso-lateral septum 95

At the time of the study in early 2024, about 0.5% of the adult population in the US was using GLP - 1 therapies

Role of funding source : Eli Lilly and Company as the funder of the study had a role in the study design, data collection, data analysis, data interpretation, and writing of the report